In Neuroscience Discovery we are looking for an experienced and curious researcher taking a leading role in developing and running mass spectrometry-based analyses supporting in vitro and in vivo activities enabling the development of future therapies in the field of Alzheimer’s and Parkinson’s disease. The lab-based position is located within the Proteostasis Team and focuses on protein homeostasis, misfolding and degradation in the context of neurodegenerative diseases.

Key responsibilities include:

• You will take a leading role in developing and running mass spectrometry-based analyses supporting in vitro and in vivo activities of Neuroscience Discovery
• As a member of the Proteostasis’ team you will design, execute, and interpret critical (phospho-) proteomic studies for demonstration of Mode-of-Action (MoA), and advancement of pipeline projects through milestones
• You will cross-functionally work together with colleagues from Computational Biology and in vivo Pharmacology, as well as global teams supporting MoA and Proof-of-Principle studies
• You will be jointly responsible for keeping our mass spectrometers and associated HPLCs operating and train less experienced colleagues in using respective instruments. You will act as a back-up for lipidome analyses.
• In the Neuroscience Discovery organization, you will engage yourself in identification & characterization of novel targets for treatment of neurodegenerative diseases, esp. Alzheimer dementia as well as Parkinson’s disease, and follow the technological landscape of mass spectrometry regarding new methods and instrumentation.

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary, ideally in chemistry, biology or pharmacy
• You gained hands-on expertise in operating mass spectrometers for at least 3 years.
• You are highly skilled in operating and daily maintenance of Nano-HPLCs and high-resolution mass spectrometers (ideally Orbitrap instruments)
• You have hands-on experience in designing and executing (phospho-) proteomic studies using cells or tissues. You are trained in DDA and DIA analyses and familiar with relevant software, e.g. MaxQuant or Spectronaut
• You are versed in general cell biology and biochemical methodology
• You are skilled to analyze and present data in broader context and eager to defend data during scientific debate
• Additional analytical/technical experience (e. g. CE-MS, automation) is beneficial
• A solid background in Neuroscience / neurodegenerative diseases is advantageous
• As a highly motivated, self-driven and results-oriented person with excellent communication skills you are driven by innovative ways of thinking to improve processes, methods, systems or services
• As a global acting company, we presume proficient English language skills and willingness to learn German

We offer you:

• A challenging job as a scientist in Neuroscience-Discovery with a strong focus on mass spectrometry-based analyses in vitro and in vivo
• Passionate and highly committed colleagues
• We are happy to accompany your on-boarding process and support you during your first steps in your new role
• We provide our employees with high flexibility to tailor their daily work to their individual needs, including flexible work models, multiple benefits, and comprehensive health and sports programs
• Attractive compensation and company benefits, including our excellent occupational health management system, which is one of the best in Germany as well as a wide range of career paths and opportunities for further development
  

At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity and affirmative action employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic. If you would like to view a copy of the company’s affirmative action plan or policy statement, please email CorpJat_ABV@abbvie.com.